Evaluation of central nervous system involvement in SLE patients. Screening psychiatric manifestations--a systematic review.

Cognitive dysfunction, mood and anxiety disorders are three out of the five psychiatric manifestations included the description of neuropsychiatric Systemic Lupus Erythematosus (SLE). These manifestations are among the most prevalent in SLE having an important impact on patients quality of life. However, the unknown etiology allied to the lack of clarity on the best diagnosis procedure, makes early diagnosis dificult. This manuscript reviews the recent literature on the screening instruments focused on identifying lupus patients with probable psychiatric manifestations.